COORDINATION POLYMERS (CPS) ARE INFINITE SYSTEMS CONTAINING METAL IONS AND ORGANIC LIGANDS LINKED VIA COORDINATION BONDS AND OTHER WEAK CHEMICAL BONDS. THEY HAVE RECEIVED SIGNIFICANT ATTENTION FOR THEIR STRUCTURAL AND DIVERSE APPLICATIONS, SUCH AS MAGNETISM, SORPTION, ELECTRICAL CONDUCTIVITY, LUMINESCENT SCIENCE AND CATALYSIS. POLYOXOMETALATES (POMS) ARE ALSO KNOWN DUE TO THEIR VARIOUS TOPOLOGICAL PROPERTIES AND APPLICATIONS IN CATALYSIS. THEY HAVE BEEN WIDELY UTILIZED AS INORGANIC BUILDING BLOCKS FOR THE CONSTRUCTION OF ORGANIC-INORGANIC HYBRID MATERIALS [1]. THE KNOEVENAGEL CONDENSATION REACTION IS ONE OF THE MOST USEFUL METHODS FOR CARBON–CARBON BOND FORMATION. IT HAS BEEN WIDELY USED FOR THE PREPARATION OF A RANGE OF SUBSTITUTED ALKENES, COSMETICS, PERFUMES AND PHARMACEUTICAL INDUSTRY. CONVENTIONALLY, KNOEVENAGEL CONDENSATION REACTIONS PROCEED HOMOGENOUSLY IN THE PRESENCE OF VARIOUS BASE CATALYSTS. UNFORTUNATELY, THE HOMOGENEOUS CATALYSIS COULD NOT SOLVE THE PROBLEM IN SEPARATION AND RECYCLING OF CATALYST. FOR THIS REASON, HETEROGENEOUS CATALYSTS HAVE BEEN USED IN KNOEVENAGEL CONDENSATION [2-3].IN THIS WORK, THE [CUI(4,4´-BIPY)]3[PMO10 VIMO2 VO40{CUII(2,2´-BIPY)}] WAS PREPARED USING COPPER SALT, 4,4´-BIPYRIDINE, 2,2´-BIPYRIDINE AND HETEROPOLYACID UNDER HYDROTHERMAL CONDITION. THE CATALYST WAS IDENTIFIED USING XRD, FT-IR AND ATOMIC ABSORPTION. THEN IT WAS USED AS HETEROGENEOUS CATALYSTS FOR KNOEVENAGEL CONDENSATION REACTION (FIG.1). IN THIS STUDY, FACTORS SUCH AS INFLUENCE OF REACTION TEMPERATURE, TIME, AMOUNT OF CATALYST, SOLVENT AND SUBSTITUTENTS OF ALDEHYDES AND MALONONITRILE HAS BEEN CONSIDERED. AFTER OPTIMIZED THE REACTION CONDITIONS, IT WAS FOUND THAT AT 60˚C IN ETHANOL WITHIN 4H, 100% CONVERSION TOWARDS THE FORMATION OF KNOEVENAGEL CONDENSATION PRODUCTS IS CONSIDERABLE.

A, B-UNSATURATED KETONE MOIETIES HAVE BEEN FOUND IN THE STRUCTURE OF MANY NATURAL AND BIOLOGICALLY ACTIVE COMPOUNDS.1 THESE COMPOUNDS COULD BE ALSO EMPLOYED AS BENEFICIAL REACTANTS IN OTHER SYNTHETIC TRANSFORMATIONS

THE KNOEVENAGEL CONDENSATION IS AN IMPORTANT TRANSFORMATION IN ORGANIC SYNTHESIS. THE REACTION IS PREDOMINATELY EMPLOYED FOR FORMATION OF C-C DOUBLE BONDS DURING THE SYNTHESIS OF A, B-UNSATURATED CARBONYL COMPOUNDS. CLASSICALLY, TETRAKETONES AND THEIR ENOL FORMS HAVE BEEN SYNTHESIZED THROUGH A COMBINATION OF THE KNOEVENAGEL…

PYRROLES ARE FOUND TO BE AS THE FUNDAMENTAL STRUCTURAL MOTIFS IN VARIOUS CLASSES OF NATURAL AND BIOLOGICALLY IMPORTANT MOLECULES SUCH AS PORPHYRINS, BILE PIGMENTS, COENZYMES, AND ALKALOIDS. THE HIGH SURFACE AREA TO VOLUME RATIO OF METAL OXIDE NANOPARTICLE IS MAINLY RESPONSIBLE FOR THEIR CATALYTIC PERFORMANCE. NANO-COPPER MATERIAL ARE OF REUSABLE CATALYSTS WHICH SHOW PROFOUND CATALYTIC ACTIVITY IN ORGANIC SYNTHESIS [4].HEREIN WE REPORT AN EFFICIENT PROTOCOL FOR THE SYNTHESIS OF POLYSUBSTITUTED PYRROLES BY USING NANO COPPER POWDER AS A RECYCLABLE CATALYST VIA THE REACTION BETWEEN Α- AMINO KETONES AND ACETYLENIC COMPOUNDS. VARIETY OF POLYSUBSTITUTED PYRROLES WERE SYNTHESIZED EFFICIENTLY IN THE PRESENCE OF CATALYTIC AMOUNT OF NANO COPPER POWDER, UNDER LIGAND FREE CONDITIONS WITH METHANOL AS SOLVENT AT 80OC. THE CATALYST IS AIR‐STABLE, INEXPENSIVE, AND RECYCLABLE UP TO FOUR CYCLES.